Publications '07 - '10

50. Toh, W. H., Nam, S. Y., & Sabapathy, K. (2010). An essential role for p73 in regulating mitotic cell death. Cell Death and Differentiation, 17(5), 787–800. https://doi.org/10.1038/cdd.2009.181

49. Gough, D. J., Messina, N. L., Hii, L., Gould, J. A., Sabapathy, K., Robertson, A. P., Trapani, J. A., Levy, D. E., Hertzog, P. J., Clarke, C. J., & Johnstone, R. W.(2010). Functional crosstalk between type I and II interferon through the regulated expression of STAT1. PLoS Biology, 8(4), e1000361. https://doi.org/10.1371/journal.pbio.1000361

48. Song, J. Y., Han, H. S., Sabapathy, K., Lee, B. M., Yu, E., & Choi, J. (2010). Expression of a homeostatic regulator, Wip1 (wild-type p53 - induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation. The Journal of Biological Chemistry, 285(12), 9067–9076. https://doi.org/10.1074/jbc.M109.070003

47. Dulloo, I., Gopalan, G., Melino, G., & Sabapathy, K. (2010). The antiapoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway. Proceedings of the National Academy of Sciences of the United States of America, 107(11), 4902–4907. https://doi.org/10.1073/pnas.0906782107

46. Chua, H. W., Ng, D., Choo, S., Lum, S. S., Li, H., Soh, L. Y., Sabapathy, K., & Seow, A. (2010). Effect of MDM2 SNP309 and p53 codon 72 polymorphisms on lung cancer risk and survival among non-smoking Chinese women in Singapore. BMC Cancer, 10, 88. https://doi.org/10.1186/1471-2407-10-88

45. Xie, M., & Sabapathy, K. (2010). Tyrosine 170 is dispensable for c-Jun turnover. Cellular Signalling, 22(2), 330–337. https://doi.org/10.1016/j.cellsig.2009.09.040

44. Baum, N., Schiene-Fischer, C., Frost, M., Schumann, M., Sabapathy, K., Ohlenschläger, O., Grosse, F., & Schlott, B. (2009). The prolyl cis/trans isomerase cyclophilin 18 interacts with the tumor suppressor p53 and modifies its functions in cell cycle regulation and apoptosis. Oncogene, 28(44), 3915–3925. https://doi.org/10.1038/onc.2009.248

43. Shin, S., Asano, T., Yao, Y., Zhang, R., Claret, F. X., Korc, M., Sabapathy, K., Menter, D. G., Abbruzzese, J. L., & Reddy, S. (2009). Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism. Molecular Cancer Research, 7(5), 745–754. https://doi.org/10.1158/1541-7786.MCR-08-0462

42. Sabapathy, K., & Nam, S. Y. (2008). Defective MHC class I antigen surface expression promotes cellular survival through elevated ER stress and modulation of p53 function. Cell Death and Differentiation, 15(9), 1364–1374. https://doi.org/10.1038/cdd.2008.55

41. Toh, W. H., Logette, E., Corcos, L., & Sabapathy, K. (2008). TAp73beta and DNp73beta activate the expression of the pro-survival caspase-2S. Nucleic Acids Research, 36(13), 4498–4509. https://doi.org/10.1093/nar/gkn414

40. Lee, M. K., & Sabapathy, K. (2008). The R246S hot-spot p53 mutant exerts dominant-negative effects in embryonic stem cells in vitro and in vivo. Journal of Cell Science, 121(11), 1899–1906. https://doi.org/10.1242/jcs.022822

39. Kolomeichuk, S. N., Terrano, D. T., Lyle, C. S., Sabapathy, K., & Chambers, T. C. (2008). Distinct signaling pathways of microtubule inhibitors--vinblastine and Taxol induce JNK-dependent cell death but through AP-1-dependent and AP-1-independent mechanisms, respectively. The FEBS Journal, 275(8), 1889–1899. https://doi.org/10.1111/j.1742-4658.2008.06349.x

38. Lum, S. S., Chua, H. W., Li, H., Li, W. F., Rao, N., Wei, J., Shao, Z., & Sabapathy, K. (2008). MDM2 SNP309 G allele increases risk but the T allele is associated with earlier onset age of sporadic breast cancers in the Chinese population. Carcinogenesis, 29(4), 754–761.

https://doi.org/10.1093/carcin/bgn024

37. Phang, B. H., Linn, Y. C., Li, H., & Sabapathy, K. (2008). MDM2 SNP309 G allele decreases risk but does not affect onset age or survival of Chinese leukaemia patients. European Journal of Cancer, 44(5), 760–766. https://doi.org/10.1016/j.ejca.2008.02.007

36. Nam, S. Y., Lee, M. K., & Sabapathy, K. (2008). The tumour-suppressor p53 is not required for pancreatic beta cell death during diabetes and upon irradiation. The Journal of Physiology, 586(2), 407–417. https://doi.org/10.1113/jphysiol.2007.142612

35. Lee, M. K., & Sabapathy, K. (2007). Phosphorylation at carboxyl-terminal S373 and S375 residues and 14-3-3 binding are not required for mouse p53 function. Neoplasia, 9(9), 690–698. https://doi.org/10.1593/neo.07511

34. Vikhanskaya, F., Toh, W. H., Dulloo, I., Wu, Q., Boominathan, L., Ng, H. H., Vousden, K. H., & Sabapathy, K. (2007). p73 supports cellular growth through c-Jun- dependent AP-1 transactivation. Nature Cell Biology, 9(6), 698–705. https://doi.org/10.1038/ncb1598

33. Phang, B. H., & Sabapathy, K. (2007). The codon 72 polymorphism-specific effects of human p53 are absent in mouse cells: implications on generation of mouse models. Oncogene, 26(21), 2964–2974. https://doi.org/10.1038/sj.onc.1210112

32. Vikhanskaya, F., Lee, M. K., Mazzoletti, M., Broggini, M., & Sabapathy, K. (2007). Cancer-derived p53 mutants suppress p53-target gene expression—potential mechanism for gain of function of mutant p53. Nucleic Acids Research, 35(6), 2093–2104. https://doi.org/10.1093/nar/gkm099

31. Hettinger, K., Vikhanskaya, F., Poh, M. K., Lee, M. K., de Belle, I., Zhang, J. T., Reddy, S. A., & Sabapathy, K. (2007). c-Jun promotes cellular survival by suppression of PTEN. Cell Death and Differentiation, 14(2), 218–229. https://doi.org/10.1038/sj.cdd.4401946

30. Li, X. M., Li, C. C., Yu, S. S., Chen, J. T., Sabapathy, K., & Ruan, D. Y. (2007). JNK1 contributes to metabotropic glutamate receptor-dependent long-term depression and short-term synaptic plasticity in the mice area hippocampal CA1. The European Journal of Neuroscience, 25(2), 391–396.

https://doi.org/10.1111/j.1460-9568.2006.05300.x

29. Gough, D. J., Sabapathy, K., Ko, E. Y., Arthur, H. A., Schreiber, R. D., Trapani, J. A., Clarke, C. J., & Johnstone, R. W. (2007). A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon gamma response genes. The Journal of Biological Chemistry, 282(2), 938–946. https://doi.org/10.1074/jbc.M607674200